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KMID : 0615720100270050025
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Jouranl of Korean Acupuncture and Moxibustion society
2010 Volume.27 No. 5 p.25 ~ p.34
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The Effect of Angelica gigas NAKAI Pharmacopuncture at ST36 and BL23 on Freund’s Adjuvant Arthritis in Rats
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Ryu Mi-Seon
Kim Jae-Hong
Yoon Yeo-Choong
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Abstract
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Objective:The purpose of this study is to investigate that effect of Angelica gigas NAKAI pharmacopuncture(AGN-Ph) by concentration at ST36(足三里) and BL23(腎兪) in Freund’s adjuvant rats.
Methods:The experimental model of arthritis was induced by injection of Freund’s adjuvant into Sprague Dawley(SD) rats. After arthritis was induced, AGN-Ph was injected by concentration at ST36 and BL23 of rats every other day for 6 times. Thereafter, edema rate, body weight, IFN-γ, TNF-α, hematologic assay were measured.
Results:The results were as follows, 1. After 3 times AGN-Ph treatment, the mean of edema rate was significantly decreased in AGN-Ph group 3 than control group. And after 6 times AGN-Ph treatment, the mean of edema rate was significantly decreased in AGN-Ph group 1, 2, 3 than control group. 2. The mean of body weight was significantly increased in AGN-Ph group 1, 3 than control group and saline group. 3. The mean of IFN-γ was significantly increased in AGN-Ph group 3 than control group. 4. The mean of TNF-α was significantly increased in saline group than control group. But the mean of TNF-α in AGN-Ph group 2, 3 showed no significance compared with control group’s. 5. In hematologic assay, levels of WBC, RBC, Hemoglobin, Hematocrit showed no significance in all groups.
Conclusions:These results are suggest that the Angelica gigas NAKAI pharmacopuncture(AGN-Ph) at ST36 and BL23 has a suppressing inflammation effect on Freund’s adjuvant arthritis in rats.
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KEYWORD
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RA(Rheumatoid arthritis), Freund’s adjuvant arthritis, Angelica gigas NAKAI pharm- acopuncture, ST36, BL23
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